Nutrition Facts:

Heart conditions are a major concern for millions of Americans. Many fight heart disease through diet and exercise while others add prescription medications to their struggle. With our heart health category, we address the needs of those looking for additional cardiovascular support through dietary supplementation. We offer unique products in this line, each with a different approach to supporting heart health. for example, Cholest-CheckTM (#081) combines four active ingredients for a multi-faceted approach at cardiovascular health.

Policosanol has gained popularity as an alternative to prescription medication. It is an effective cholesterol support product that does not cause a deficiency of CoQ10, the main reason for aches and pains associated with cholesterol drugs. Policosanol is a mixture of nine high primary aliphatic alcohols, formulated to maintain healthy levels of both LDL and HDL cholesterol. Octacosanol, the main ingredient in Policosanol, is a powerful antioxidant that helps to keep arteries healthy. The octacosanol used in our product is a derivative of sugar cane wax, not beeswax or rice bran as is sometimes used in other policosanol formulas.

Niacin is another popular approach to supporting healthy cholesterol. The benefits of vitamin B3 for cardio health are well demonstrated, but some people complain of a flushing of the face after taking large doses. Inositol hexanicotinate is a form of niacin that is absorbed slowly by the body, not reaching full serum levels for nearly ten hours after consumption. Inositol hexanicotinate is not timed release niacin, it is a wholly separate type of vitamin B3 designed to provide all of the benefits of traditional niacin without the flush.

Garlic has been used as herbal medication for thousands of years for everything from bubonic plague to food for workers on the great pyramids. Its health-promoting properties are mostly credited to the sulfuric amino acid called alliin that occurs in garlic. Alliin, however, is not fully effective until converted to allicin, which is the component that gives garlic its therapeutic effects. Heat inactivates alliinase, the enzyme responsible for the conversion of alliin to allicin. This may explain why it is recommended that raw garlic be used for health instead of cooked garlic.

All of this considered, many people do not like taking multiple supplements. This is why we have developed Cholest-CheckTM (#081), a four pronged approach to cholesterol health. In addition to policosanol and inositol hexanicotinate, described above, we have included CoQ10 and Activin® grape seed extract for extra support. CoQ10 is a critical enzyme both in the Krebs cycle and in the production of ATP, the body’s energy producing unit. CoQ10 levels are also often depleted by the use of cholesterol medications, which block production of HMG-CoA reductase, a catalyst in the production of mevalonic acid. Mevalonic acid is then processed by the liver and transformed into cholesterol. The problem is that HMG-CoA reductase is also crucial in the production of CoQ10, which the body needs to bring energy to cells. This is why many people experience minor aches and pains when taking cholesterol medication.

Activin® grape seed extract is an effective antioxidant backed by clinical research shown to not only promote cardiovascular health, but also protect against damage caused by external toxins and maintain healthy cells.

Heart Health Marketing Opportunities:
• Cholesterol support is the fastest-growing segment in the dietary supplement market
• Products affect cholesterol differently, and may be sold in combination for maximum results
• Target market to heart health
• Innovative Cholest-CheckTM Formula combines ingredients not used together in any other product
• Products use capsule and tablet form
• Provides a wide array of cholesterol support products for your own label to compete with brands

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any diseases.

No. No-flush niacin is a completely different form of niacin than timed release. It is broken down more slowly by the digestive system and does not reach full blood serum levels for nearly ten hours after ingestion. This is actually a longer period of time than many timed release niacin supplements.

The main problem with many cholesterol drugs is that when taken over a long period of time, they begin to lower levels of the important co-enzyme CoQ10. Policosanol has a similar mechanism of action to these drugs without lowering CoQ10 levels.

Many drugs inhibit the expression of the enzyme HMG-CoA reductase, which is a catalyst in the production of mevalonic acid. Mevalonic acid is then processed by the liver and transformed into cholesterol. So, it would reason, the less HMG-CoA reductase in one’s system, the less mevalonic acid and, hence, less cholesterol. But it is not so simple. HMG-CoA reductase should not be completely eliminated in order to lower cholesterol. Low levels are beneficial to a point, and then can become counter productive.

HMG-CoA reductase is also used in the formation of farnesyl diphosphate or FPP. FPP, though used in squalene, another cholesterol precursor, is also used in production of CoQ10. Not enough FPP, and not enough CoQ10 will be produced. This is why some drugs which inhibit HMG-CoA reductase expression have the nasty side effect of lowered CoQ10 levels. Policosanol, on the other hand, inhibits expression by only about 50%, which is not enough to significantly affect production of FPP.

As opposed to some products which feature an enteric coating to reduce reflux and odor, our High-Allicin Garlic (#082) uses only titanium dioxide mined from the earth. This safe, all-natural coating achieves the same effect as an enteric coating without having to use artificial plasticizers.

Our new High-Allicin Garlic (#082) formula contains at least 10,000ppm (10mg per gram) of allicin and 22,000ppm (22mg per gram) of alliin. High levels of these active components make our High-Allicin Garlic (#082) a potent supplement for cholesterol support. This calculates to at least 5mg of allicin per tablet.

Our policosanol contains at least 50% octacosanol, a derivative of sugar cane wax grown in the Suzhoo province of China. It also contains eight other high primary aliphatic alcohols that are included in policosanol as follows:

Triacontanol 15-30%
Hexacosanol 10-20%
Dotriacontanol 0.5-5%
Tetracosanol 0.5-5%
Heptacosanol <5%
Nonacosanol <5%
Hentriacontanol <2%
Pentacosanol <2%

There are a few reasons for our inclusion of CoQ10 in Cholest-CheckTM (#081). First, this product may be used by those currently taking cholesterol medications. This is a market that needs CoQ10 to replace what is not being made because of the drugs. CoQ10 is also an important factor in the production of ATP, the body’s energy delivery system. The more efficiently energy is produced from food, the less will be stored as fat, and the less cholesterol in the bloodstream. Basically, if energy production is more efficient, the heart can be healthier.

CoQ10 is also involved in the Krebs cycle. Again, if this cycle is more efficient, less food will be stored as fat and less cholesterol will be floating around the body. Though CoQ10 is involved in scores of other reactions, these are the most relevant to cholesterol and cardiovascular health, and thus are the basis for its inclusion in Cholest-CheckTM (#081).

People taking cholesterol medication can benefit especially from this formula because it contains antioxidants as well as CoQ10, a coenzyme that can become quickly depleted in customers taking such drugs. Though policosanol’s mechanism of action is not unlike that of some cholesterol medications, it also is a powerful antioxidant that can help maintain healthy levels of both LDL and HDL cholesterol.

The inositol hexanicotinate used in no-flush niacin in 90.4% niacin and 9.6% inositol. If you do the math that breaks down to 454mg of niacin and 46mg of inositol per dose. This is over 2000% of the recommended daily intake.

There is no difference. They are different names for the same molecular compound. It is probably best just to refer to it as no-flush niacin so as not to confuse customers.

Yes.

Homocysteine is an amino acid that is usually broken down and released from the body with no harm done. Some people have a genetic flaw that leaves them deficient in the enzymes responsible for regulation and breakdown of homocysteine, and this toxic amino acid builds up in their system leading to major cardiac events. This is often the case when young, healthy people inexplicably suffer a stroke or heart attack. Even those without the genetic flaw are susceptible, with typical risk factors such as smoking, obesity, and environmental stresses. The B vitamins included in Homocysteine Support Formula (#251) work in conjunction with the methyl cell donor trimethylglycine the breakdown and removal of homocysteine from the system.

TMG acts as a methyl donor in the homocysteine metabolism cycles. It can donate methyl groups to the homocysteine molecule in much the same way vitamins B6 and B12 do, assisting in the conversion to methionine. TMG is also an effective methyl donor because when it loses its third methyl group through donation, it becomes dimethylglycine, a nutrient known to help boost energy. TMG also contributes to the production of S-adenosylmethionine (SAMe), an important substance for neurotransmitter production.